Preservation of renal function in cardiac surgery patients with low cardiac output syndrome: levosimendan vs beta agonists
Not Applicable
Completed
- Conditions
- ow cardiac output syndrome (LCOS)Circulatory System
- Registration Number
- ISRCTN46058317
- Lead Sponsor
- FIMABIS
- Brief Summary
2019 results in: ncbi.nlm.nih.gov/pubmed/31735161 (added 19/11/2019)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
1. Patients older than 18 years who developed postoperative low cardiac output syndrome (LCOS) following heart surgery
2. LCOS (was defined as: a cardiac index < 2l/min/m2, or central venous saturation <65% after volume replacement) . It was checked by echocardiogram and Mostcare® (continuous cardiac index monitoring)
3. Patients who required inotropic support for the treatment of LCOS
Exclusion Criteria
1. Patients who required combined surgery (not only cardiac surgery)
2. Emergency surgery
3. Preoperative diagnosis of chronic kidney failure
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> Renal function parameters:<br> 1. Creatinine measured using ELISA at baseline, 24 and 48 hours and ICU discharge<br> 2. Stage of renal failure measured by the Acute renal failure (AKI) scale at baseline, 24 and 48 hours and ICU discharge<br> 3. Diuresis and use of diuretics (mg of furosemide) measured using diuresis output at baseline, 24 and 48 hours and ICU discharge<br> 4. Requirement of renal replacement therapy measured using dialysis therapy at ICU discharge<br>
- Secondary Outcome Measures
Name Time Method <br> Hemodynamics:<br> 1. HR (arrhythmia de novo) measured using EKG at baseline, 24 and 48 hours and ICU discharge<br> 2. Multifocal atrial tachycardia (MAT) measured using EKG at baseline, 24 and 48 hours and ICU discharge<br> 3. Heart failure (HF) measured using locs definition at baseline, 24 and 48 hours and ICU discharge<br> 4. Ejection fraction of the left ventricle (EFLV) measured using Echo at baseline, 24 and 48 hours and ICU discharge<br> 5. SvcO2 measured using oximetry at baseline, 24 and 48 hours and ICU discharge<br> 6. Central venous pressure (CVP) measured using pressure transductor at baseline, 24 and 48 hours and ICU discharge<br>