The Effects of Interval Compared to Continuous Training on Physical Variables and Vascular Health in College Students: A Three-Arm Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Change in Central Augmentation Index (cAIx)
研究概览
简要总结
The purpose of this study is to compare two types of exercise programs in college students: high-intensity functional training and moderate-intensity continuous training. The study evaluates whether these exercise programs improve body composition, physical fitness, and blood vessel health compared with a group that does not participate in exercise training. In addition, the study examines whether changes in body composition and physical fitness are associated with changes in blood vessel health.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18 to 35 years.
- •Currently enrolled college or university student.
- •Able to provide written informed consent.
- •Able to attend baseline and post-intervention testing visits and participate in assigned intervention sessions.
- •Cleared for exercise participation based on the health screening form and investigator review.
排除标准
- •Known cardiovascular, metabolic, pulmonary, renal, neurological, musculoskeletal, or endocrine disorder that would make exercise unsafe or confound outcome measures.
- •Current pregnancy or planning pregnancy during the study period.
- •Current smoking, vaping nicotine products, or use of tobacco products.
- •Uncontrolled hypertension or resting blood pressure values that make exercise testing unsafe based on investigator judgment.
- •Use of medications known to substantially affect cardiovascular function, vascular tone, or exercise responses, unless approved by the PI.
- •Any injury, orthopedic limitation, or medical condition preventing safe participation in HIFT, MICT, or physical fitness testing.
- •Currently participating in structured high-intensity interval, functional, or endurance training more than two days per week during the previous three months.
- •Do not speak English.
结局指标
主要结局
Change in Central Augmentation Index (cAIx)
时间窗: Baseline and Week 10 (post-intervention)
The central augmentation index (cAIx), expressed as a percentage, will be assessed at baseline and post-intervention using the SphygmoCor XCEL device via pulse wave analysis of the central arterial waveform derived from carotid artery tonometry and peripheral blood pressure measurements.
Change in Carotid-Femoral Pulse Wave Velocity (cfPWV)
时间窗: Baseline and Week 10 (post-intervention)
Carotid-femoral pulse wave velocity (cfPWV) will be measured in meters per second (m/s) at baseline and post intervention as an indicator of arterial stiffness. Measurement will be obtained using the SphygmoCor XCEL device (AtCor Medical) with upper arm and thigh cuffs with carotid artery applanation tonometry to assess pulse wave transit time
Change in Mean Arterial Pressure (MAP)
时间窗: Baseline and Week 10 (post-intervention)
Mean arterial pressure (MAP), measured in millimeters of mercury (mmHg), will be assessed at baseline and post-intervention. MAP will be assessed using the SphygmoCor XCEL system (AtCor Medical) based on an algorithm derived from peripheral blood pressure obtained via an automated upper arm cuff.
Percent Change in Flow-Mediated Dilation (FMD)
时间窗: Baseline and Week 10 (post-intervention)
Flow-Mediated Dilation (FMD) will be measured at baseline and post-intervention using a Philips Affiniti 50 ultrasound system and expressed as the percent (%) change in brachial artery diameter from pre-occlusion baseline to peak dilation following a 5-minute forearm occlusion. The outcome will be reported as the change in FMD (%) from baseline to post-intervention.
Change in Carotid Intima-Media Thickness (cIMT)
时间窗: Baseline and Week 10 (post-intervention)
Carotid intima-media thickness (cIMT), measured in millimeters (mm), will be assessed using a Philips Affiniti 50 ultrasound system at baseline and post-intervention. High-resolution B-mode images of the distal common carotid artery will be acquired, and mean wall thickness will be calculated from standardized image segments of the left and right carotid arteries.
次要结局
- Change in Body mass index (BMI)(Baseline and Week 10 (post-intervention))
- Change in Waist Circumference (WC)(Baseline and 10 weeks (post-intervention))
- Change in Body fat percentage (BF%)(Baseline and 10 weeks (post-intervention))
- Change in Skeletal Muscle Mass (SMM)(Baseline and 10 weeks (post-intervention))
- Change in visceral adipose tissue (VAT)(Baseline and 10 weeks (post-intervention))
- Change in Muscular Strength(Baseline and Week 10 (post-intervention))
- Change in Cardiorespiratory Fitness(Baseline and Week 10 (post-intervention))
- Change in Muscular Endurance(Baseline and Week 10 (post-intervention))
- Change in Flexibility (Sit-and-Reach test)(Baseline and Week 10 (post-intervention))
- Change in Flexibility (Trunk Lift test)(Baseline and Week 10 (post-intervention))
研究者
Arlette Perry
Professor
University of Miami