The evaluation of symptom and pathophysiological changes after 20mg of esomeprazole administration by 24-hour intraesophageal pH/impedance (MII-pH) monitoring.
Not Applicable
- Conditions
- PPI-resistant gastro-esophageal reflux disease
- Registration Number
- JPRN-UMIN000009264
- Lead Sponsor
- Division of Gastroenterology, Aichi Medical University School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Not provided
Exclusion Criteria
(1)alarm sign such as vomitting or gastrointestinal bleeding (2)Zollinger Ellison syndrome, esophageal stenosis, achalasia, cerebrovascular disorder (3)Serious hepatic disorder, renal disease, heart disorder (4)malignant disorder (5)A pregnant woman, nursing mother or the woman who may be pregnant. (6)In addition, clinical studies supervisor or the study attending physician judged the subject to be inadequate to attend this study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method symptom, QOL, neurosis evaluation by questionnaire
- Secondary Outcome Measures
Name Time Method pathophysiology of GERD by 24-hour intraesophageal pH/impedance monitoring, HP infection, gastric mucosal atropy, CYP2C19 genetic polymorphism