Effects of Curcumin on Vascular Reactivity

Phase 1

Completed

• Conditions: Healthy Volunteers (Middle-aged Smokers)
• Interventions: Drug: Curcumin

• Registration Number: NCT01543386
• Lead Sponsor: University Hospital, Clermont-Ferrand

Brief Summary

The aim of this study is to determine if an oral loading-dose of curcumin can improve vascular endothelium reactivity in patients with moderate cardiovascular risk

Detailed Description

The aim of this study is to determine if an oral loading-dose of curcumin can improve vascular endothelium reactivity in patients with moderate cardiovascular risk

Study Timeline

• Study Start: 2012-02
• Study First Submitted: 2012-02-16
• Study First Submitted QC: 2012-02-27
• Study First Posted: 2012-03-05
• Primary Completion: 2012-04
• Study Completion: 2012-04
• Status Verified: 2014-07
• Last Update Submitted: 2014-07-04
• Last Update Posted: 2014-07-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

• 50 to 70 year-old volunteers
• smokers

Exclusion Criteria

• treated hypertension
• treated hypercholesterolemia
• chronic disease
• vegetarian or other unusual diets
• chronic alcoholism

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
curcumin	Curcumin	The aim of this study is to determine if an oral loading-dose of curcumin can improve vascular endothelium reactivity in patients with moderate cardiovascular risk

Primary Outcome Measures

Name	Time	Method
Changes in brachial Flow Mediated Dilatation	at Visit 1 (Day 0) and visit 2 (Day3/day5)

Secondary Outcome Measures

Name	Time	Method
Changes in fingertip arterial tonometry	at visit 1 (day 0) and visit 2 (day3/day5)
Modifications of leukocytes transcriptome	at visit 1 (day 0) and visit 2 (day3/day 5)

Trial Locations

Locations (1)

CHU Clermont-Ferrand; 🇫🇷 Clermont-Ferrand, France