Heart Rate Variability in Children With Traumatic Brain Injury and Neurological Outcome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- % of the time with reliable HRVmonitoring in children with TBI
研究概览
简要总结
Using a prospective cohort of children admitted to the PICU, the investigators will determine HRV monitoring is feasible, if a decreased HRV in the 7 days following moderate or severe TBI in children is associated with a worse outcome 6 months post-TBI and investigate HRV as a tool that can predict adverse events (neurological crisis) within 2 days following TBI.
详细描述
This is a single center prospective cohort study of 15 children <18 years, admitted to the PICU at the CHU Sainte-Justine (CHUSJ) with moderate or severe TBI (<24 hours). Neurodevelopment outcome of children will be evaluated 6 months post TBI.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 0 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •<18 years
- •admitted to the PICU at the CHUSJ
- •moderate TBI (Glasgow Coma Scale (GCS): 9-12) or severe TBI (GCS ≤8) as - - assessed 30 minutes after TBI or upon arrival in the emergency room
- •written parental consent.
排除标准
- •children fulfilling brain death criteria at the time of PICU admission (GCS 3 and loss of all brain stem reflexes)
- •children with a pacemaker or with previously diagnosed arrhythmia (HRV monitoring not reliable)
- •inflicted trauma (different underlying pathophysiology)
- •patients or parents who do not speak or read English or French.
结局指标
主要结局
% of the time with reliable HRVmonitoring in children with TBI
时间窗: 1 year
Feasibility of having a reliable capture and analysis of HRV 7 days post TBI
次要结局
- Rate of adverse events preceded by a decreased HRV(1 year)
- HRV and neurological outcome(1.5 year)
研究者
Laurence Ducharme-Crevier
Pediatric intensivist, Principal Investigator
St. Justine's Hospital