rTMS-induced Cumulative Pattern of sBDNF in Chronic Schizophrenia
- Conditions
- Schizophrenia
- Interventions
- Device: CR Technology, TAMAS for repetitive TMS
- Registration Number
- NCT01427088
- Lead Sponsor
- Jeonbuk Provincial Maeumsarang Hospital
- Brief Summary
This study aims at investigating the neuroplastic potential and the possible factors affecting rehabilitation in chronic schizophrenia patients on stable medication, by investigating the cumulative pattern of serum BDNF representing the neuroplasticity in the brain, through quantitative stimulus such as rTMS.
- Detailed Description
Subjects who have been enrolled for this study will take baseline evaluation for sociodemographic data and serum level of BDNF, plasma Prolaction, and magnesium, etc. And then, weekday regular stimulation through rTMS will be applied on DLPFC of brain. After the completion of stimulation for 2 weeks, the change or response of serum BDNF will be analyzed and compared.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 21
- duration of illness over 10 years
- on stable medication, antipsychotics
- no change on medication within at least 2 weeks
- Diagnosis of Schizophrenia according to DSM-IV-TR
- left or both-handedness
- anticonvulsant use
- lorazepam equivalent over 3 mg
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description repetitive TMS CR Technology, TAMAS for repetitive TMS repetitive TMS is a quantified stimulation method of specifie area of brain, for which CR Technology, TAMAS for repetitive TMS was used.
- Primary Outcome Measures
Name Time Method change from baseline of serum BDNF concentration baseline-1 week-2 week-4 week
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Jeonbuk Provincial Maeumsarang Hospital
🇰🇷Wanju, Jeonbuk, Korea, Republic of