Human Chorionic Gonadotropin (hCG) Priming Prior to Controlled Ovarian Hyperstimulation (COH) in Poor Responder In Vitro Fertilization (IVF) Patients

Phase 4

Completed

• Conditions: Ovarian Response

• Registration Number: NCT00870025
• Lead Sponsor: IVI Madrid

Brief Summary

There is a decline in androgen concentration with ovarian aging. Also, ovarian response to COH in IVF cycles diminishes with ovarian aging. Recent evidence suggest that testosterone or DHEA may improve ovarian response in poor prognosis patients by increasing intraovarian androgen concentration. A physiological way to induce androgen synthesis within the ovary is to stimulate theca cells androgen production by hCG stimulation. By doing this in the previous cycle we might expect a better response to COH.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-10
• Study First Submitted: 2008-10-25
• Study First Submitted QC: 2009-03-25
• Study First Posted: 2009-03-26
• Primary Completion: 2010-09
• Study Completion: 2010-09
• Status Verified: 2015-04
• Last Update Submitted: 2015-04-21
• Last Update Posted: 2015-04-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

• previous IVF cycle with 5 or less mature follicles or 5 or less oocyte retrieved

Exclusion Criteria

• 42 years or older
• BMI <18 or >30

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
pregnancy rate	2 weeks after intervention

Secondary Outcome Measures

Name	Time	Method
number of oocytes retrieved	2 weeks after intervention

Trial Locations

Locations (1)

IVI-Madrid; 🇪🇸 Madrid, Spain