Randomized Trial With Dendritic Cells in Patients With Metastatic Colorectal Cancer

Phase 2

Completed

• Conditions: Colorectal Neoplasms
• Interventions: Drug: Dendritic Cell Vaccine; Other: Supportive treatment

• Registration Number: NCT01413295
• Lead Sponsor: Fundacion Clinic per a la Recerca Biomédica

Brief Summary

The different alternatives used since 1996 to treat metastatic colorectal cancer (MCRC) have increased the mean survival of these patients. This outstanding advance is due to the extended indications for resection of hepatic metastases and to the use of new chemotherapeutic drugs (fluoropyrimidine, irinotecan and oxaliplatin) and monoclonal antibodies (bevacizumab, cetuximab and panitumumab). However, none of these treatments is curative and the majority of patients are overwhelmed by the illness. The first line of treatment for MCRC is FOLFOX and the second, irinotecan plus cetuximab for patients with wild type KRAS gene (60%) with a 30% responses, and bevacizumab plus irinotecan with a 5-10% of responses, in patients with mutated KRAS (40%). A treatment with autologous dendritic cells (DCs) pulsed with autologous tumour antigens is proposed as a third line of therapy. A randomized phase II trial would be performed, by selecting two groups of patients, one of them would be treated with the best supportive treatment and the other with DCs plus the best supportive treatment. The aim of the study would be to analyze the outcome after 4 months of treatment. In patients treated with DCs, IFN-γ spot forming cells and proliferative responses would be determined pre and post treatment in lymphocytes stimulated with autologous DCs pulsed with autologous tumour antigens. Pre and post treatment serum levels of IFN-γ, TNF-α, TGF-β e IL-12, would also be measured.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-08
• Study First Submitted: 2011-08-09
• Study First Submitted QC: 2011-08-09
• Study First Posted: 2011-08-10
• Primary Completion: 2014-09
• Study Completion: 2014-09
• Status Verified: 2014-11
• Last Update Submitted: 2014-11-03
• Last Update Posted: 2014-11-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 52

Inclusion Criteria

• Age over 18 years.
• Capacity of understanding and signing the informed consent and to undergo the study procedures.
• Previously treated with 2 lines of chemotherapy.
• ECOG <= 2.
• Adequate renal, hepatic and bone marrow function
• Confirmed diagnosis of colorectal cancer with hepatic metastasis, suitable for biopsy.
• Availability of tumor tissue, for maturing dendritic cells
• RECIST.1 criteria

Exclusion Criteria

• Clinically relevant diseases or infections (HBV, HCV, HIV).
• Pregnant or breast feeding women.
• Immunosuppressant treatment.
• Concurrent cancer, with the exceptions allowed by the principal investigator (PI).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Dendritic Cells Vaccine	Dendritic Cell Vaccine	Dendritic Cells Vaccine after 2 lines of chemotherapy
Supportive treatment	Supportive treatment	Supportive treatment after 2 lines of chemotherapy

Primary Outcome Measures

Name	Time	Method
Progression Free Survival	4 months

Secondary Outcome Measures

Name	Time	Method
Overall Survival	4 months

Trial Locations

Locations (1)

Hospital Clínic Barcelona; 🇪🇸 Barcelona, Spain