CTRI/2020/02/023116尚未招募1 期
Safety and efficacy of Sacubitril/Valsartan in control of resistant hypertension in CKD 5D patients
试验速览
- 阶段
- 1 期
- 状态
- 尚未招募
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Patients declared as CKD 5D
- •Aged >18 years
- •Resistant hypertension
- •Non oliguric
- •Definitions
- •CKD 5D- defined as hemodialysis dependence since last 3 months prior to screening
- •Resistant hypertension- defined as uncontrolled hypertension SBP > 140 mm Hg or DBP >90 mm Hg despite use of 3 or more antihypertensive drugs including a diuretic
- •Non oliguric- defined as urine output more than 200 ml per day
排除标准
- •Serum potassium >5.5 mg/dl
- •Not giving consent
- •History of angioedema
- •History of intolerance to ACE-inhibitors/ ARBs
- •Associated heart failure with reduced ejection fraction
- •Alanine aminotransferase or Aspartate aminotransferase >2 times the upper limit of the normal range
- •Not willing for thrice a week hemodialysis
研究者
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