Effects of Non-invasive Mechanical Ventilation on Hemodynamics and Gas Exchanges Parameters After Cardiac Surgery in Patients With Relative Hypoxemia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Heart; Dysfunction Postoperative, Cardiac Surgery
- Sponsor
- Irmandade Santa Casa de Misericórdia de Porto Alegre
- Enrollment
- 42
- Locations
- 1
- Primary Endpoint
- Oxygenation index (PaO2/FiO2)
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
Non-invasive mechanical ventilation (NIV) has been used in hypoxic post-operative cardiac patients but more studies are necessary to clarify its respiratory and hemodynamic effects. Therefore, the investigators objective was to study its effects in the oxygenation index (PaO2/FiO2) and in hemodynamic variables in this group of patients.
Detailed Description
* Postoperative cardiac surgery patients having a Swan-Ganz catheter and showing a PaO2/FiO2 between 150 and 300 (with FIO2 0.31), one hour after extubation, were included. * Then, the patients were randomized into two groups: control and intervention group. Intervention group used NIV with a bi-level positive airway pressure (an inspiratory pressure to generate a tidal volume of 6ml/kg and an expiratory pressure of 7cmH2O) with a FIO2 0.4. Control group used oxygen by Venturi mask(FIO2 0.4) in order to keep a good oxygenation. * In both groups measurements were done in basal situation, one and three hours after beginning the treatment and one hour after stop the treatment (FiO2 0.31). * Variables studied included: PaO2/FiO2, PaO2, PaCO2, heart rate (HR), mean arterial pressure (MAP), pulmonary capillary wedge pressure (PCWP) and cardiac output (CO).
Investigators
Alessandra Preisig
Principal Investigator
Irmandade Santa Casa de Misericórdia de Porto Alegre
Eligibility Criteria
Inclusion Criteria
- •Oxygenation index (PaO2/FiO2)between 150 and 300 one hour after extubation following cardiac surgery.
- •Swan-Ganz catheter
Exclusion Criteria
- •Invasive mechanical ventilation more than 24 hours
- •Serious obstructive pulmonary chronic disease (FEV1\<40%)
Outcomes
Primary Outcomes
Oxygenation index (PaO2/FiO2)
Time Frame: 5 hours
Secondary Outcomes
- Heart rate (HR)(5 hours)
- Mean arterial pressure (MAP)(5 hours)
- Pulmonary capillary wedge pressure (PCWP)(5 hours)
- Cardiac output (CO)(5 hours)