Comparing the Antibacterial Effect of 810 nm Diode Laser and Photodynamic Therapy

Phase 2

• Conditions: Periradicular Disease
• Interventions: Device: diode laser; Drug: Methylene blue

• Registration Number: NCT02555488
• Lead Sponsor: Shahid Beheshti University

Brief Summary

The aim of this study was to compare the Antibacterial Efficacy of Diode Laser 810nm and Photodynamic therapy in reducing bacterial microflora in endodontic retreatment of teeth with periradicular lesion.

Detailed Description

Conventional techniques of root canal treatments such as mechanical instrumentation and chemical debridement with antimicrobial irrigants, such as Sodium hypochlorite (NaOCl) and chlorhexidine and use of calcium hydroxide do not always suffice to predictably render root canals free of bacteria Using the high-power diode laser is a new approach of disinfection allowing access to the previously unavailable areas, such as the tubular network. This study, therefore, compares two types of diode lasers (low-power and high power) in terms of anti-bacterial effect as well as the conventional endodontic retreatment to determine the ideal method of root canal disinfection.

Study Timeline

• Study Start: 2015-01
• Status Verified: 2015-09
• Study First Submitted: 2015-09-15
• Study First Submitted QC: 2015-09-18
• Last Update Submitted: 2015-09-18
• Study First Posted: 2015-09-21
• Last Update Posted: 2015-09-21
• Primary Completion: 2015-10
• Study Completion: 2015-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• endodontic retreatment of teeth with periradicular lesion.

Exclusion Criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
2	diode laser	in the second group diode laser (810 nm, 1.2 W, 30 s) was irradiated. Then second samples were taken from all canals.
1	Methylene blue	In the first group Photodynamic therapy (PDT) with Methylene blue and diode laser (810 nm, 0.2 W, 40 second) was done
1	diode laser	In the first group Photodynamic therapy (PDT) with Methylene blue and diode laser (810 nm, 0.2 W, 40 second) was done

Primary Outcome Measures

Name	Time	Method
bacterial colony forming unit(CFU/ML)	12 months	after doing protocol in each groups CFU /ml for different bacteria will be counted

Trial Locations

Locations (1)

Shahid Beheshti University; 🇮🇷 Tehran, Iran, Islamic Republic of