The effect of high dose of vitamin C on brain acute phase biomarker in patients with diffuse axonal brain injury .

Rasht University of Medical Sciences0 个研究点目标入组 90 人开始时间: 待定最近更新: 2022年4月4日

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•Adult patients aged 16 years or older and <60 years
•Moderate to severe diffuse axonal injury with a Glasgow coma score of 4 to12
•Admission with diagnosis of diffuse brain injury as defined by ICD-10 S06.2 within the first 24 hours of injury
•Radiological diagnosis of diffuse axonal brain injury

•Patients with a specific pathology on a CT scan of the brain that is inconsistent with the diagnosis of DAI
•Patients with acute and chronic liver injuries
•Ptients with acute and chronic renal insufficiency and those at high risk for urinary stones.
•people with underlying conditions such as uncontrolled diabetes, high blood pressure , chronic obstructive pulmonary disease , blood diseases ,Malnutrition or unusual diets.
•Previous central nervous system injury , concomitant spinal cord injury, space-occupying lesions requiring emergency evacuation
•Patients whose guardians do not consent to participate in the study
•patients with a previous diagnosis of severe psychiatric illness or substance abuse
•patients with shock or hypoxia or Cardiopulmonary arrest following trauma.

发起方

Rasht University of Medical Sciences