The Prevalence, Disease Course, Prognosis and Interaction of Chronic Obstructive Pulmonary Disease With Pulmonary Hypertension
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 1,708
- 试验地点
- 1
- 主要终点
- COPD exacerbations
研究概览
简要总结
Pulmonary hypertension is a common complication of chronic obstructive pulmonary disease (COPD). It is reported that over half of COPD patients develop pulmonary hypertension. COPD and pulmonary hypertension may have pathological or genetics interactions so that patients having both disorders tend to have poor prognosis. Echocardiography is widely used to detect pulmonary hypertension, but it's not accurate enough. Therefore, high-quality data reflecting the prevalence, disease course and outcome of pulmonary hypertension in COPD is very limited in China. The aim of the study is to detect pulmonary hypertension with right heart catheterization, describe its outcome in Chinese COPD patients and explore the underlying interaction mechanism.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Stable chronic obstructive pulmonary disease (COPD) patients
排除标准
- •Patients with other serious respiratory diseases
- •Patients with pulmonary hypertension other than group 3
- •Patients with right heart hypertrophy or dysfunction not caused by chronic obstructive pulmonary diseases
- •Patients with limited life expectancy
- •Patients with history of tracheal intubation or stoke, acute coronary syndrome in 6 months
- •Psychopath or addict
结局指标
主要结局
COPD exacerbations
时间窗: 3 years
total hospitalizations times due to COPD exacerbations
次要结局
- modified British medical research council (mMRC) score(3 years)
- transplant-free survival rate(3 years)
- COPD Assessment Test (CAT) score(3 years)
- 6 minutes walk distance(3 years)
研究者
Jianguo He
Chief of Pulmonary Vascular Disease Center
Chinese Academy of Medical Sciences, Fuwai Hospital