The Prevalence, Disease Course, Prognosis and Interaction of Chronic Obstructive Pulmonary Disease With Pulmonary Hypertension
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- COPD
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
- Enrollment
- 1708
- Locations
- 1
- Primary Endpoint
- COPD exacerbations
- Last Updated
- 8 years ago
Overview
Brief Summary
Pulmonary hypertension is a common complication of chronic obstructive pulmonary disease (COPD). It is reported that over half of COPD patients develop pulmonary hypertension. COPD and pulmonary hypertension may have pathological or genetics interactions so that patients having both disorders tend to have poor prognosis. Echocardiography is widely used to detect pulmonary hypertension, but it's not accurate enough. Therefore, high-quality data reflecting the prevalence, disease course and outcome of pulmonary hypertension in COPD is very limited in China. The aim of the study is to detect pulmonary hypertension with right heart catheterization, describe its outcome in Chinese COPD patients and explore the underlying interaction mechanism.
Investigators
Jianguo He
Chief of Pulmonary Vascular Disease Center
Chinese Academy of Medical Sciences, Fuwai Hospital
Eligibility Criteria
Inclusion Criteria
- •Stable chronic obstructive pulmonary disease (COPD) patients
Exclusion Criteria
- •Patients with other serious respiratory diseases
- •Patients with pulmonary hypertension other than group 3
- •Patients with right heart hypertrophy or dysfunction not caused by chronic obstructive pulmonary diseases
- •Patients with limited life expectancy
- •Patients with history of tracheal intubation or stoke, acute coronary syndrome in 6 months
- •Psychopath or addict
Outcomes
Primary Outcomes
COPD exacerbations
Time Frame: 3 years
total hospitalizations times due to COPD exacerbations
Secondary Outcomes
- modified British medical research council (mMRC) score(3 years)
- transplant-free survival rate(3 years)
- COPD Assessment Test (CAT) score(3 years)
- 6 minutes walk distance(3 years)