Early-onset Pneumonia After Out-of-hospital Cardiac Arrest
- Conditions
- Out-of-Hospital Cardiac Arrest
- Registration Number
- NCT03355885
- Lead Sponsor
- University Hospital, Brest
- Brief Summary
Early-onset pneumonia after out-of-hospital cardiac arrest is frequent. An association between early-onset pneumonia and an increase in morbidity has been reported in this population. The diagnosis of early-onset pneumonia inpatients with out-of-hospital cardiac arrest may be challenging as diagnosis criteria are unspecific in this setting. On the other hand some studies have reported an association between early antibiotics and better prognosis in patients with out-of-hospital cardiac arrest suggesting that early diagnosis and treatment of pneumonia would benefit to patients. Nonetheless, adminitration of antibiotics to any patients with out-of-hospital cardiac arrest would expose to antibiotic patients without infection and woould participate to increase in antibiotic resistance.
Therefore, the PP-ACR study aims to evaluate the impact of a diagnosis algorithm including blinded sampling protected brushes on early-onset pneumonia treatment and patient prognosis after out-of-hospital cardiac arrest.
- Detailed Description
This study is a single centre observational study with a before - after design.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 240
- patients admitted for out-of-hospital cardiac arrest and treated with hypothermia
- age less than 18
- consent withdrawal
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method delta respiratory SOFA score between Day 1 and day 3 first 3 days delay between intensive care admission and antibiotic initiation first 5 days
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
CHRU de Brest
🇫🇷Brest, France