Predictors of Early Chest Infection in Acute Ischemic Stroke
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 530
- Locations
- 1
- Primary Endpoint
- diagnosis of chest infection within 7 days after stroke
Study Overview
Brief Summary
Pneumonia is a frequent complication of acute stroke and is associated with increased mortality and long-term impairment in the affected subjects. In previous studies, a number of clinical (e.g., dysphagia, severe neurological impairment, mechanical ventilation), radiological (e.g., large infarctions in the territory of middle cerebral artery, insular infarction) and biochemical (e.g., increased serum levels of C-reactive protein, decreased levels of CD4+ T-lymphocytes) findings have been reported as risk factors of stroke-related chest infection. The present study (PRECAST) aims to identify a small set out of these previously described risk factors that can predict stroke-related pneumonia with high sensitivity and specificity.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •acute ischemic stroke
- •admission to the neurological intensive care unit or stroke unit within 24 hours after stroke onset
- •clearly assessed brain lesion location
Exclusion Criteria
- •previous large (non-lacunar) stroke
- •chest infection present already on hospital admission
- •mechanical ventilation already on day 1 or 2 after hospital admission
- •treatment with immunosuppressive drugs
Outcomes
Primary Outcomes
diagnosis of chest infection within 7 days after stroke
Time Frame: days 1-7 after stroke
Secondary Outcomes
No secondary outcomes reported