Assessment of Coronary Artery Disease in Stroke Patients

Completed

• Conditions: Coronary Artery Disease

• Registration Number: NCT01850693
• Lead Sponsor: Seoul National University Hospital

Brief Summary

This study is to evaluate the prevalence, plaque characteristics (plaque types, stenosis degree, remodeling) and predictors of coronary atherosclerosis in stroke patients with coronary CT angiography.

Detailed Description

Stroke and coronary artery disease (CAD) share common risk factors and pathological mechanisms. CAD is an important cause of death in patients with stroke.

Currently, coronary CT angiography (CCTA) is very useful non-invasive tool for detection of CAD and plaque analysis.

Therefore, the investigators aimed to evaluate the prevalence, plaque characteristics (plaque types, stenosis degree, remodeling) and predictors of CAD in stroke patients through follow-up (more than 5 years) using CCTA.

Study Timeline

• Study Start: 2006-07
• Primary Completion: 2012-12
• Status Verified: 2013-05
• Study First Submitted: 2013-05-03
• Study First Submitted QC: 2013-05-06
• Study First Posted: 2013-05-09
• Study Completion: 2015-06
• Last Update Submitted: 2015-11-08
• Last Update Posted: 2015-11-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1657

Inclusion Criteria

• Acute stroke patients who diagnosed by clinical and brain MR imaging
• Who performed coronary CT angiography within 3 months after acute stroke

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Exclusion Criteria

• intracranial hemorrhage including intracerebral, subdural or subarachnoid hemorrhage
• brain tumor
• Previous myocardial infarction
• Previously performed percutaneous coronary intervention (PCI), coronary artery bypass graft (CABG) or other cardiac surgery
• Insufficient medical record
• Poor image quality of CCTA scan

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MACE (Major Adverse Cardiac Event)	Participants will be followed until June. 2015, an expeded average of 5 years	MACE was included as follows: 1) all-cause mortality, 2) myocardial infarction, 3) unstable angina requiring hospitalization

Secondary Outcome Measures

Name	Time	Method
Any cardiac events	Participants will be followed until June. 2015, an expeded average of 5 years	1) late revascularization: who underwent revascularization therapy mroe than 90days after CCTA and referral due ot new symptoms or an abnormal function test, 2) heart failure required hospitalization.

Trial Locations

Locations (1)

Seoul National University Bundang Hospital; 🇰🇷 Seongnam-si, Gyeonggi-do, Korea, Republic of