The Effect of Non-surgical Periodontal Therapy With or Without Systemic Administration of Amoxicillin and Metronidazole on Serum Levels of TRAP-5b in Patients With Generalized Chronic Periodontitis - A Comparative Clinical Study
Overview
- Phase
- Not Applicable
- Intervention
- Scaling and root planing
- Conditions
- Chronic Periodontitis
- Sponsor
- Meenakshi Ammal Dental College and Hospital
- Enrollment
- 30
- Primary Endpoint
- Serum levels of TRAP-5b
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
To compare the effect of non-surgical periodontal therapy with or without systemic administration of amoxicillin and metronidazole on the concentration of serum levels of TRAP-5b in patients with generalized chronic periodontitis.
Detailed Description
30 Chronic periodontitis subjects were divided into two groups- group A underwent scaling and root planing and group B underwent scaling and root planing with systemic administration of amoxicillin of 500 mg and metronidazole of 400 mg thrice daily for 7 days. Periodontal parameters probing pocket depth and clinical attachment level were measured at baseline and at 3rd month. Serum TRAP-5b levels were also measured at baseline, 1 month and at 3rd month.
Investigators
Dr.Jaideep Mahendra
Professor
Meenakshi Ammal Dental College and Hospital
Eligibility Criteria
Inclusion Criteria
- •Presence of atleast 20 teeth
- •more than 30% of sites with clinical attachment loss of ≥ 5 mm
- •non-smokers
- •no previous history of periodontal therapy
Exclusion Criteria
- •systemic diseases
- •under antibiotics or anti-inflammatory drugs within previous 3 months
- •pregnant and lactating women
- •allergic to antibiotics
Arms & Interventions
Group A -control group
15 subjects underwent scaling and root planing
Intervention: Scaling and root planing
Group B-Interventional group
15 subjects underwent scaling and root planing along with antibiotic intervention of amoxicillin of 500 mg and metronidazole of 400 mg thrice daily for 7 days
Intervention: scaling and root planing along with antibiotic intervention
Outcomes
Primary Outcomes
Serum levels of TRAP-5b
Time Frame: Baseline and 3 months
Concentration of serum levels of TRAP-5b was assessed at baseline and at 3rd month using ELISA method.
Secondary Outcomes
- Clinical attachment level(Baseline and 3 months)
- Probing pocket depth(Baseline and 3 months)