Impact of Nonsurgical Periodontal Therapy in association with Probiotic in the intestinal and oral microbiome: a randomized, double-blind, placebo-controlled clinical trial

Faculdade de Odontologia da Universidade Federal do Rio de Janeiro0 个研究点开始时间: 2018年10月18日最近更新: 2023年5月29日

适应症

试验速览

暂无简介。

•Subjects with eighteen years or more; who have at least fourteen natural teeth, excluding third molars; and advanced chronic periodontitis which is determined as pocket probing depth equal or greater than six mm in three or more periodontal sites and bleeding on probing in twenty percent of the sites examined.

•Exclusion criteria are the need for antibiotic prophylaxis; having received antibiotics therapy in the three-month period prior to the study; having received periodontal therapy in the six-month period prior to the study; chronic gastrointestinal diseases or abnormalities of the gastrointestinal tract; metabolic disorders; cardiovascular diseases; immunological disorders; HIV infection; be a smoker or have stopped smoking in less than
•five years; ongoing orthodontic treatment; have Body Mass Index equal or greater than twenty-five; be pregnant or breastfeeding, if woman.

发起方

Faculdade de Odontologia da Universidade Federal do Rio de Janeiro