Acute intravascular volume transfers during isometric leg exercise

• Conditions: circulatie fysiologie; (low) blood pressure; fainting

• Registration Number: NL-OMON30131
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 8

Inclusion Criteria

healthy normotensive individuals (age 20-35 yr, BMI 20-25, height 160-190 cm)

Exclusion Criteria

-use of any medication that interferes with cardiovascular regulation.
-(suspected) pregnancy or desire to become pregnant in the period of the study
-(suspected) cardiovascular disease
-presence of any circumstance that is likely to interfere with normal orthostatic tolerance and/or the use of LBNP and/or MR-Imaging
-wish not to be informed about significant irregularities from MRI;Students and employees of the AMC can not take part in study.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Volumes of legs, liver, spleen and heart during stages of LBNP with and without<br /><br>isometric leg exercise.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.a.</p><br>