Study on the Analgesic Effect and Central Mechanism of Tuina Treatment for Knee Osteoarthritis

Phase 1

Recruiting

• Conditions: Knee Osteoarthritis

• Registration Number: ITMCTR2100004865
• Lead Sponsor: Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1.Comply with KOA's diagnostic criteria of Chinese and Western medicine, meanwhile, the TCM syndrome is of Qi stagnation and blood stasis syndrome;
2.Aged 50 to 75 years, male and female, left knee pain, right handed;
3.Kellgren-Lawrence radiology score is II-III Points;
4.Knee joint pain lasts for more than 6 months;
5.VAS score >= 3 points;
6.Occupation: non-manual workers (such as teachers, corporate office staff, etc.), no daily strenuous lower limb activities;
7.Agree and sign an informed consent.

Exclusion Criteria

1.Patients with damaged skin around the knee joint;
2.Patients with knee surgery history and history of severe trauma;
3.Secondary KOA, patients with rheumatoid arthritis, gouty arthritis, infectious arthritis and other joint diseases;
4.With diabetes , Systemic infections, severe liver and kidney function abnormalities, malignant tumors and other diseases;
5.Patients have received other treatment measures within the past month;
6.Patients are allergic to celecoxib capsules;
7.Pregnant or lactating women;
8.Mental disorders or cognition People with known dysfunction;
9.Suffering symptoms of the digestive system: such as active digestive ulcer/bleeding, or recurring ulcer/bleeding;
10.Patients with MRI contraindications such as locaphoresis, pacemakers, defibrillators, cardiac stents and intrauterine devices.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pressure pain thresholds;MRI scan to obtain various modal parameters;

Secondary Outcome Measures

Name	Time	Method
umerical pain score;Pain catastrophizing scale;Hamilton anxiety scale;Hamilton depression scale;