Study on the central mechanism of analgesic effect of Tuina on knee osteoarthritis based on multimodal MRI

Phase 1

Recruiting

• Conditions: Knee Osteoarthritis

• Registration Number: ITMCTR2000003262
• Lead Sponsor: Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Inclusion criteria of patients with knee osteoarthritis
1. 50-70 years old;
2. It was diagnosed as osteoarthritis of knee joint and agreed to participate in this experiment;
3. All of them are right handed;
4. KL Level 2 or 3;
5. The pain time of knee joint is more than or equal to 3 months;
6. Agree and sign the informed consent.
Inclusion criteria for healthy volunteers
1. Right handedness;
2. The age range is 50-70 years old;
3. No history of chronic pain;
4. In the past 1 month, he did not receive medication, physical therapy or massage therapy;
5. Understand the process of the study, agree and sign the informed consent.

Exclusion Criteria

1. Patients taking analgesics or anti-inflammatory analgesics within the past 1 month;
2. Patients who received any other treatment within the past month;
3. Pregnant or lactating women;
4. Patients with mental disease, neurological disease, infectious disease, gastrointestinal disease, cardiovascular and cerebrovascular disease, immunologic disease, respiratory disease or kidney disease;
5. Patients with tumor, tuberculosis, rheumatism or rheumatoid arthritis, gout, joint trauma, or any other chronic pain symptoms, or with a history of brain injury with loss of consciousness;
6. Patients with MRI contraindications such as atresia phobia, pacemaker, defibrillator, cardiac stent, intrauterine device, etc..

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MRI scan to obtain various modal parameters;

Secondary Outcome Measures

Name	Time	Method
Pressure Pain Thresholds;Hamilton Depression Rating Scale;