Clinical analgesic effect and Mechanism of Massage manipulation in the treatment of knee Osteoarthritis

Phase 1

• Conditions: Knee osteoarthritis

• Registration Number: ITMCTR1900002387
• Lead Sponsor: Shanghai University of Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. repeated knee joint pain in the past 1 month;
2. X-ray films (standing position or load-bearing position) showed narrowing of joint space, subcartilage osteosclerosis and / or cystic degeneration, and formation of osteophyte at the edge of the joint;
3. Aged = 50 years old;
4. Morning stiffness time = 30 min;
5. there is bone friction sound (feeling) during the activity.
Osteoarthritis of knee joint can be diagnosed by meeting the diagnostic criteria of 1 + (any 2 of 2, 3, 4 and 5).

Exclusion Criteria

1. there was skin damage around the knee joint;
2. patients with history of knee surgery and severe trauma;
3. patients with secondary OA, complicated with rheumatoid arthritis, gouty arthritis, infectious arthritis and other joint diseases;
4. patients with diabetes mellitus, systemic infection, severe abnormal liver and kidney function, malignant tumor and other diseases;
5. the patients were treated with non-steroidal anti-inflammatory drugs and intra-articular injection in the past 3 months.
6. those who were allergic to drugs in this study;
7. pregnant or lactating women;
8. patients with mental disorder or cognitive dysfunction;
9. those who did not accept or could not adhere to the treatment plan of this study.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
PPT;