Ankle Dorsiflexion Splinting Enhances Endothelial Function of Aged Leg Muscles
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 17
- 试验地点
- 2
- 主要终点
- Change in vascular endothelial function of leg conduit artery
研究概览
简要总结
Endothelial function of the skeletal muscle vasculature declines with advancing age. Although aerobic exercise training is commonly prescribed to combat loss of endothelial function in the elderly, the rate of compliance to training programs is low. Contrary to aerobic exercise training, stretching exercise is widely performed in elderly patients to increase muscle flexibility and to prevent muscle atrophy induced by immobilization. However, it remains unknown as to whether regular stretching of the calf muscles using ankle dorsiflexion splinting improves muscle blood flow. The purpose of the proposed work is to test the hypothesis that performance of ankle dorsiflexion splinting improves endothelial function and lower leg muscle blood flow in older adults. Ankle dorsiflexion splinting will be performed on the randomized leg for 30 minutes, 5 times per week for 4 weeks. Leg vascular measures will be performed on the splinted and non-splinted legs prior to and at the end of the 4-week intervention.
详细描述
Older adults will be recruited in this study. Vascular function will be assessed before and after the 4-week ankle splinting intervention. To examine the acute effects of splinting, vascular measures will also be obtained before and immediately following 30 min of ankle splinting. All procedures will be performed at the Integrative Cardiovascular Physiology Laboratory at the University of Florida.
Participants will have one leg randomly assigned to using a splint to stretch the calf muscles 30 min per day, 5 days per week for 4 weeks, while the contralateral non-splinted leg will serve as an internal control.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women aged 60 to 79 years.
- •Women will all be postmenopausal and must not take hormone replacement therapy.
- •Sedentary, defined as no regular exercise training.
排除标准
- •No evidence of heart disease evidenced by abnormal resting ECG, angina or ECG evidence of acute myocardial ischemia during the exercise test, no history of any relevant acute cardiac event (myocardial infarction, episode of heart failure)
- •No history of deep vein thrombosis.
- •No history of Type I or II diabetes mellitus.
- •No history for renal or liver disease.
- •No history of seizures, or other relevant on-going or recurrent illness.
研究组 & 干预措施
Ankle splinting
Older adults will have one leg randomly assigned to ankle splinting for 4 weeks. The non-splinted leg will serve as the control.
干预措施: Ankle splinting (Other)
No Ankle Splinting
The non splinted leg will serve as the control
结局指标
主要结局
Change in vascular endothelial function of leg conduit artery
时间窗: At baseline and after 4 weeks of ankle splinting
Endothelium-dependent and endothelium-independent dilation of popliteal artery using ultrasonography.
次要结局
- Change in vascular endothelial function of calf resistance vessels(At baseline and after 4 weeks of ankle splinting)
- Change in calf blood flow in response to acute ankle splinting(Before and after 30 min of ankle splinting)