Impact of N-Acetylcysteine on Oxidative Stress and Renal Function in Deceased Kidney Transplant Recipients

Not Applicable

Completed

• Conditions: Deceased Kidney Transplantation
• Interventions: Drug: N-acetylcysteine

• Registration Number: NCT00851708
• Lead Sponsor: University of Sao Paulo

Brief Summary

The aim of this interventional, prospective, randomized clinical trial is to evaluate the impact of the antioxidant N-acetylcysteine on oxidative stress in the first seven postoperative days and on renal function in the first three postoperative months in deceased kidney transplantation.

Detailed Description

Not available

Study Timeline

• Status Verified: 2009-02
• Study First Submitted: 2009-02-25
• Study First Submitted QC: 2009-02-25
• Study First Posted: 2009-02-26
• Last Update Submitted: 2009-02-27
• Last Update Posted: 2009-03-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• First transplant
• Deceased kidney transplant

Exclusion Criteria

• postoperative recovery at critical care unit
• illicit drug addiction
• psychiatric disorders

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
NAC	N-acetylcysteine	treatment

Primary Outcome Measures

Name	Time	Method
Tiobarbituric acid reactive species measures	First seven postoperative days

Secondary Outcome Measures

Name	Time	Method
Serum creatinine	7, 15, 30, 60, 90 postoperative day

Trial Locations

Locations (1)

Clinics Hospital, University of Sao Paulo, Medical School; 🇧🇷 São Paulo, Brazil