Changes in hormonal levels of cortisol and ACTH after taking dexamethasone tablet in the night
Phase 2
- Conditions
- Health Condition 1: K732- Chronic active hepatitis, not elsewhere classifiedHealth Condition 2: N184- Chronic kidney disease, stage 4 (severe)Health Condition 3: N185- Chronic kidney disease, stage 5Health Condition 4: E243- Ectopic ACTH syndromeHealth Condition 5: F339- Major depressive disorder, recurrent, unspecifiedHealth Condition 6: E248- Other Cushings syndromeHealth Condition 7: E240- Pituitary-dependent Cushings disease
- Registration Number
- CTRI/2024/03/063793
- Lead Sponsor
- Seth GS Medical College Multidisciplinary Research Unit
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Newly diagnosed cushings
Cushings post surgery or radiotherapy
Chronic active hepatitis
Depressive disorder
CKD stage 4 and 5
Women on oral contraceptive pills
Healthy controls
Exclusion Criteria
Exogenous cushings
Drugs affecting dexamethasone metabolism
Pregnancy and breastfeeding
Acute illness
Liver cirrhosis
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To establish normative data of ACTH and cortisol after overnight dexamethasone suppression in various patient groupsTimepoint: 1 year
- Secondary Outcome Measures
Name Time Method ILTimepoint: NIL <br/ ><br>