Effects of Omega-3 Supplementation, associated or not with High-intensity Physical Training on anthropometric, physiological, biochemical and molecular parameters in patients with Metabolic Syndrome

niversidade Federal de Juiz de Fora0 个研究点开始时间: 2022年5月24日最近更新: 2023年5月29日

适应症

试验速览

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•Both sexes; age between 20 and 60 years; diagnosis of grade I obesity (Body Mass Index between 30.0 and 34.9 kg/m²) and type 2 diabetes mellitus; exclusive use of metformin; no evidence of coronary artery disease (history of angina, history of myocardial infarction or acute coronary syndrome, history of abnormal segmental motion of the heart wall on echocardiography); no bowel disease (short bowel syndrome, irritable bowel syndrome, Chron's disease, ulcerative colitis, celiac disease, colorectal cancer); no diseases related to the central nervous system (Alzheimer's, Parkinson's, hepatic encephalopathy, autism spectrum disorders); physical inactivity according to the International Physical Activity Questionnaire (short version); signing the informed consent form (ICF).

•Individuals with musculoskeletal or cardiovascular limitations that make physical exercise impossible; fasting blood glucose greater than 300 mg/dl; use of any drug of continuous use for less than 3 months (except metformin); use of antibiotics, non-steroidal anti-inflammatory drugs or corticosteroids in the last month; use vitamin/food supplements that contain omega-3; individuals with genetic and hormonal limiting disease; abuse of alcohol and drugs; retinopathy; pregnancy or lactation; life expectancy less than 6 months (example: metastatic malignant neoplasm); patients with renal failure or congestive heart failure; individuals with previous organ transplants; wheelchair users; individuals with weight loss in the last 3 months (voluntary or not); volunteers in another experimental study on the date of enrollment; individuals who do not have access to the internet; discontinuation of omega-3/placebo use for 3 consecutive days; non-compliance with the physical activity protocol for 2 consecutive sessions.

发起方

niversidade Federal de Juiz de Fora