Varicella-Zoster-Virus vaccination in immunosuppressed children with rheumatic diseases using a pre-vaccination checklist

German Center for Pediatric and Adolescent Rheumatology0 个研究点目标入组 25 人开始时间: 2018年2月12日最近更新: 2019年2月11日

适应症

试验速览

•1. Negative medical history for chickenpox and herpes zoster, corroborated by negative VZV-IgG level
•2. Not more than 1 prior dose of the VZV vaccine
•3. Diagnosis of an inflammatory pediatric rheumatic disease
•4. Clinical inactive pediatric rheumatic disease
•5. No change of IS for at least 3 months prior to the vaccination

•1. Acute febrile disease
•2. Current clinical or laboratory evidence for lack of immunologic reactivity
•3. Known hypersensitivity to constituents of the varicella vaccine
•4. Measles, mumps, rubella (MMR) vaccination within 4 weeks prior to VZV vaccination
•5. Treatment with immunosuppressive therapy other than those mentioned in the pre-vaccination checklist, i.e. i.v. glucocorticoid pulse therapy or a prednisone-equivalent dose of more than 2mg/kg/day or more than 20mg/day for > 2 weeks within less than 4 weeks prior to vaccination, cyclophosphamide pulse <6 months ago, rituximab without B-cell reconstitution, intravenous immune globulins (IVIG) <6 months ago (high-dose IVIG (2g/kg) <11 months), therapy with aspirin until 6 week post-vaccination or any blood products <3 months prior to vaccination

发起方

German Center for Pediatric and Adolescent Rheumatology