临床试验/NCT04477564

NCT04477564已完成不适用

Screening of Clonal Hematopoiesis of Indeterminate Potential in Venous Thromboembolism

Centre Hospitalier Universitaire de Nīmes1 个研究点分布在 1 个国家目标入组 150 人开始时间: 2020年7月3日最近更新: 2025年12月4日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方
入组人数: 150
试验地点: 1
主要终点: DNMT3A mutations screening

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

The aim of the study is to investigate the existence of clonal hematopoiesis of indeterminate potential (CHIP) in patients with a history of venous thromboembolism.

The study investigators make the assumption that these patients present mutations involved in CHIP occurrence.

研究设计

研究类型: Observational
观察模型: Case Crossover
时间视角: Retrospective

入排标准

年龄范围: 50 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Men and women over 50 years old who have consulted at the Hematology laboratory of the Nîmes University Hospital for the occurrence or history of venous thromboembolism
•Patient who has accepted that their DNA was kept and used in the context of research on venous thromboembolism (biobank (registration number DC-2008-290 and authorization number AC-2008-107))

排除标准

•Patients less than 50 years old
•Patient who has refused that their DNA was kept and used in the context of research on venous thromboembolism

结局指标

主要结局

DNMT3A mutations screening

时间窗: For sequencing analysis: 2 months

Next generation sequencing

次要结局

TET2, ASXL1, TP53, JAK2, SF3B1, SRSF2, GNB1, CBL, BCOR, SH2B3, PPM1D mutations screening(For sequencing analysis: 2 months)

研究者

发起方

Centre Hospitalier Universitaire de Nīmes

申办方类型

Other

责任方

Sponsor

研究点 (1)

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