Clonal Hematopoiesis of Indeterminate Potential and Residual Cardiovascular Event Tendency After Smoking Cessation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,029
- 试验地点
- 1
- 主要终点
- prevalence of CHIP mutations
研究概览
简要总结
In order to identify the association between clonal hematopoiesis of indeterminate potential (CHIP) and cardiovascular risks after smoking cessation, this study intends to recruit ACS patients undergoing complete revascularization and perform whole-exome sequencing for enrolled patients to identify the prevalence of CHIP mutations. After 1-year follow-up, the relationship of presence of CHIP mutations and the occurrence of MACCEs will be explored, irrespective of smoking cessation or not. CHIP may be a potential risk factor of poor prognosis of ACS.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •1. In-patients with acute coronary syndrome to undergo PCI
- •Complete revascularization during the index hospitalization
- •Written informed consent
排除标准
- •1. Periprocedural complications (coronary artery dissection, perforation, myocardial infarction, stroke, death)
- •Planned coronary revascularization at discharge
- •Patients with severe chronic disease (uremia, liver cirrhosis, COPD (chronic obstructive pulmonary disease)
- •Abnormal blood counts caused by hematological diseases
- •Diagnosed malignancy
结局指标
主要结局
prevalence of CHIP mutations
时间窗: 24 hours
Whole-exome sequencing is performed to detect the presence of CHIP mutations
次要结局
- MACCE(1 year)
研究者
Han Yaling
Director of cardiology, Shenyang Northern Hospital
Shenyang Northern Hospital