Is Clonal Hematopoiesis of Indeterminate Potential Associated With Unprovoked Pulmonary Embolism?
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 544
- 试验地点
- 1
- 主要终点
- Variation of CHIP markers between patients groups
研究概览
简要总结
The clonal hematopoiesis of indetermined prognosis (CHIP) has been described as risk factor for juvenile atherosclerosis. Moreover, some of CHIP genes are responsible of myeloproliferative disorders. Venous thrombosis are frequent in these disorders. The purpose of this project is to determine if CHIP is frequent in unprovoked pulmonary embolism and could be part of the pathophysiology.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •For cases : Previous proximal unprovoked pulmonary embolism, negative thrombophilia screening.
- •For control : Previous proximal provoked pulmonary embolism, negative thrombophilia screening.
排除标准
- •Age superior to 65 years old,
- •Active cancer
研究组 & 干预措施
Previous proximal unprovoked pulmonary embolism
干预措施: blood sample (Biological)
Previous proximal provoked pulmonary embolism
干预措施: blood sample (Biological)
结局指标
主要结局
Variation of CHIP markers between patients groups
时间窗: up to 2 years
Variation of CHIP markers (clonal hematopoiesis of indetermined prognosis ) between patients groups. CHIP concept have been defined as a mutation of preleukemic genes at an allelic variation inferior to 2% associated with normal complete blood count.
次要结局
未报告次要终点