NCT01358604已完成不适用
ROR1 as a Novel Target for Neuroblastoma
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 主要终点
- ROR1 is expressed on the surface of neuroblastoma cells and constitutes a suitable target for mAb therapy
研究概览
简要总结
RATIONALE: Studying samples of tissue and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study studies biomarkers in samples from young patients with neuroblastoma.
详细描述
OBJECTIVES:
Primary
- To analyze the expression of ROR1 on the surface of primary neuroblastoma cells.
- To investigate the therapeutic potential of anti-ROR1 monoclonal antibodies (mAbs), bispecific antibodies, and immunotoxins in in vitro and in vivo models of neuroblastoma.
OUTLINE: Archived bone marrow and tumor tissue samples are analyzed for ROR1 expression by flow cytometry, western blotting, qPCR, and IHC.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 120 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
ROR1 is expressed on the surface of neuroblastoma cells and constitutes a suitable target for mAb therapy
次要结局
未报告次要终点
研究者
相似试验
已完成
不适用
Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or GanglioneuroblastomaGanglioneuroblastomaLocalized Resectable NeuroblastomaLocalized Unresectable NeuroblastomaRegional NeuroblastomaStage 4 NeuroblastomaStage 4S NeuroblastomaNCT00904241Children's Oncology Group10,000
撤回
1 期
Riluzole in Women With Stage I, Stage II, or Stage IIIA Breast CancerBreast CancerNCT00903214Barbara Ann Karmanos Cancer Institute
进行中（未招募）
1 期
Engineered Neuroblastoma Cellular Immunotherapy (ENCIT)-01GanglioneuroblastomaNeuroblastomaNCT02311621Seattle Children's Hospital65
已完成
不适用
DNA Analysis of Bone Marrow and Blood Samples From Young Patients With Acute Myeloid Leukemia or Acute Lymphoblastic LeukemiaLeukemiaNCT00899652Children's Oncology Group149
已完成
不适用
Identifying Cancer Genes in in Blood and Bone Marrow Samples From Patients With Acute Myeloid LeukemiaLeukemiaNCT00897182Alliance for Clinical Trials in Oncology96