Investigating the effect of Curcumin on vincristine-induced neuropathy

Phase 3

• Conditions: europathy.; Drug-induced polyneuropathy; G62.0

• Registration Number: IRCT20201107049296N3
• Lead Sponsor: Iran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 13 November 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 140

Inclusion Criteria

Consent of parents or children older than 13 years to participate in the study
Age range from 5 to 18 years
Children who have recently been diagnosed with ALL and have not yet started treatment with vincristine

Exclusion Criteria

Congenital malformations and developmental disoreders
Primary central nervous system involvement
History of taking anti-inflammatory and antioxidant drugs
Under treatment with other drugs leading to nephropathy
Presence of neuropathy before treatment with vincristine

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Presence or absence of neuropathy. Timepoint: Before intervention and 3 months after the intervention. Method of measurement: EMG, NCV and the 12 canial nerve examinations.

Secondary Outcome Measures

Name	Time	Method
Severity of neuropathy. Timepoint: Before intervention and 3 months after the intervention. Method of measurement: EMG, NCV and clinical examinations of 12 nerves.