Can Ventilatory Response at Rest Predict Ventilatory Efficacy and Exercise Tolerance in Patients With a Univentricular Congenital Heart Disease?
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Univentricular Heart
- Sponsor
- University Hospital, Montpellier
- Enrollment
- 32
- Locations
- 2
- Primary Endpoint
- Pearson correlation - The measure the respiratory drive to hypercapnia with P0.1 during the rebreathing technique at rest
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The aim is to evaluate the correlation between the respiratory control to hypercapnia at rest and the VE/VCO2 slope measured during cardiopulmonary exercise testing.
The hypothesis is that patient with univentricular congenital heart disease have a increasing of respiratory drive like chronic heart failure. This increasing of respiratory drive could participate in the increasing of VE/VCO2 slope measured during cardiopulmonary exercise testing and in the genese of central apnea index during the sleep.
Detailed Description
The patients with univentricular congenital heart disease will perform : * a cardiopulmonary exercise testing with measure VE/VCO2 slope, * a measure of the respiratory drive to hypercapnia with occlusion pressure during the rebreathing with at rest (P0,1/PetCO2). * A polysomnography with a scoring of central apnea index. Correlation will be evaluate between P 0,1/PetCO2 with VE/VCO2 slope and between P0,1/PetCO2 central apnea index.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Functionally univentricular congenital heart disease
- •Age ≥ 8 years
- •Consent of the adult patient or the parents or legal guardians of the minor patient.
- •Beneficiary of the social security scheme
Exclusion Criteria
- •Size \<120 cm (minimum size for the stress test)
- •Medical contraindication to exercise test or presence of : myocardial infarction less than 3 months old, unstable angina, uncontrolled severe arrhythmias, symptomatic aortic stenosis, uncontrolled heart failure, pulmonary embolism, evolutionary phlebitis, pericarditis, myocarditis, progressive endocarditis, aortic dissection
- •Unstable patient with severe intellectual disability or complex pathology making polysomnography impossible
- •Pregnant woman
Outcomes
Primary Outcomes
Pearson correlation - The measure the respiratory drive to hypercapnia with P0.1 during the rebreathing technique at rest
Time Frame: day 90 after inclusion visit (visit 2)
between the measure the respiratory drive to hypercapnia with P0.1 during the rebreathing technique at rest - between VE/VCO2 slope during a cardiopulmonary exercise
Secondary Outcomes
- Pearson correlation(day 90 after inclusion visit (visit 2))