Ventilatory Variables in Subjects With Acute Respiratory Distress Syndrome Due to COVID-19
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- Death
研究概览
简要总结
Research question: Are the ventilatory variables related to mechanical power associated with the outcome of subjects who received mechanical ventilation (MV) for Acute Respiratory Distress Syndrome (ARDS) secondary to pneumonia (NMN) due to COVID-19?
详细描述
Primary Objective:
- To evaluate the association between the ventilatory variables of mechanical power and the outcome of the subjects in terms of mortality, days on MV and days free of MV at 28 days (both in survivors).
Secondary Objectives:
- Evaluate the association of demographic and gas exchange variables with the outcome of the subjects.
METHODOLOGY
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Confirmed diagnosis of pneumonia due to COVID-
- •Need of mechanical ventilation in intensive care unit.
排除标准
- •Patients with data loses
结局指标
主要结局
Death
时间窗: april 2020 to august 2021
Death in intensive care unit
global mechanical power
时间窗: april 2020 to august 2021
0,098 × Tidal Volume × Respiratory Rate × (Peak Pressure - ½ Driving Pressure)
Suvival
时间窗: april 2020 to august 2021
discharge alive from intensive care unit
Resistive mechanical power
时间窗: april 2020 to august 2021
0,098 × Tidal Volume × Respiratory Rate × (Peak Pressure - Plateau Pressure)
Ciclic Strain
时间窗: april 2020 to august 2021
Driving Pressure x 4 + Respiratory Rate
Elastic Dynamic mechanical power
时间窗: april 2020 to august 2021
0,098 × Tidal Volume × Respiratory Rate × 0,5 × Driving Pressure
Elastic static mechanical power
时间窗: april 2020 to august 2021
0,098 × Tidal Volume × Respiratory Rate × PEEP
次要结局
- ventilatory rate(april 2020 to august 2021)
- PaO2/FiO2(april 2020 to august 2021)
研究者
Marco Guillermo Bezzi
Licenciado Kinesiólogo Fisiatra
Hospital Donación Francisco Santojanni