Epidemiology and Natural History of, and riskfactors for Primary Sclerosing Cholangitis &Primary Biliary Cirrhosis in central Netherlands.
Recruiting
- Conditions
- primary sclerosing cholangitisprimary biliary cirrhosispopulation-based epidemiologycase-control studyrisk factorsnatural history
- Registration Number
- NL-OMON27701
- Lead Sponsor
- C.IJ. Ponsioen, MD PhD
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 1800
Inclusion Criteria
1. Age ≥ 18 years;
2. At least at one point during the period 1-1-2000 and 1-1-2007 resident in the abovementioned area;
Exclusion Criteria
Inability to give informed consent.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. True population-based point-prevalence (2006) and inferred incidence of newly diagnosed cases (2000-2006);<br /><br>2. Natural history with respect to death, liver<br>transplantation, occurrence of cholangiocarcinoma and colorectal carcinoma.
- Secondary Outcome Measures
Name Time Method Relative risk determination of several putative environmental, behavioural and genetic risk factors between PSC and PBC as well as background population.