Effect of Different Speed of Normal Saline Injection on Optic Nerve Sheath Diameter During Thoracic Epidural Catheterization
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- optic nerve sheath diameter change among 4 time period
研究概览
简要总结
It is reported that optic nerve sheath diameter increases when higher volume of medication is injected during epidural anesthesia.
This study is designed to compare the optic nerve sheath diameter using 10cc of nomal saline of different speed (3cc/sec vs. 1cc/sec).
详细描述
It is known that insufficient intraoperative or postoperative management can lengthen the hospital stay with unwanted complications. Therefore, active and proper management using continuous thoracic epidural catheterization is suggested good option to prevent such potential complication.
According to previous study, injection of different volume of local anesthetics (1.0 ml/kg vs. 1.5 ml/kg) during caudal anesthesia, high volume of local anesthetics resulted in significant increase of intracranial pressure (ICP). Increase of ICP can reduce regional cerebral flow and oxygen saturation causing the safety of patients. In addition, increase of ICP can result in headache, syncope, and transient loss of visual acuity.
Although it is very invasive method, ICP can be measured directly at the brain parenchyme. Among methods to measure the ICP indirectly, measurement of optic nerve sheath diameter using ultrasound is known to reflect the degree of ICP. It is reported that optic nerve sheath diameter increases when higher volume of medication is injected during epidural anesthesia.
This study is designed to compare the optic nerve sheath diameter using 10cc of nomal saline of different speed (3cc/sec vs. 1cc/sec).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •lung cancer
- •liver cancer
- •stomach cancer
- •pancreas cancer
排除标准
- •coagulopathy
- •infection
- •previous spine fusion at thoracic level
- •previous brain surgery
研究组 & 干预措施
Rapid speed of injection
Rapid speed of injection (3cc/sec) during thoracic epidurography thoracic epidural catheterization
干预措施: thoracic epidural catheterization (Other)
Slow speed of injection
Slow speed of injection (1cc/sec) during thoracic epidurography thoracic epidural catheterization
干预措施: thoracic epidural catheterization (Other)
结局指标
主要结局
optic nerve sheath diameter change among 4 time period
时间窗: Baseline, 1 minutes, 10 minutes, 30 minutes after the completion of the intervention
optic nerve sheath diameter change among 4 time period using ultrasound
次要结局
未报告次要终点
研究者
Ji Hee Hong
Professor
Keimyung University Dongsan Medical Center