Cross-modal plasticity in the auditory cortex of pre- and postlingual deaf patients
- Conditions
- Deafnesshearing impairment1001399510019243
- Registration Number
- NL-OMON47655
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
In order to be eligible to participate in the complete study, a subject must meet all of the following criteria:
- Age between 18 and 60 years
- Normal or corrected to normal vision
- Normal literacy in the Dutch or English language;Additional inclusion criteria for the three studied groups:
Hearing control group
- Hearing thresholds for individual frequencies tested in standard audiometry (125, 250, 500, 1000, 2000, 4000, and 8000 Hz) <= 30 dB HL, and the average threshold over 500, 1000, 2000 and 4000 Hz <= 20 dB HL
Prelingual deaf group
- Congenital deafness or onset of deafness before the age of 4 years
- No use of hearing aids or in case of use of conventional hearing aid, a speech perception score below 60% ;Postlingual deaf group
- Onset of deafness after the age of 7 years
- No use of hearing aids or in case of use of conventional hearing aid, a speech perception score below 60%
Not fulfilling the criteria of the standard 7 Tesla fMRI inclusion list, including the presence of any type of metal in the body, tattoos on the skin and pregnancy.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter of the fMRI experiment is the difference in Blood<br /><br>Oxygenation Level Dependent (BOLD) signal changes in the auditory cortex in<br /><br>response to visual stimuli between deaf adults and hearing controls.<br /><br><br /><br>The main study parameter of the memory experiment is the difference in percent<br /><br>correct scores in spatial and temporal memory tasks between hearing and deaf<br /><br>adults.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary parameters of the fMRI experiment are the locations and spatial<br /><br>organization of visually evoked Blood Oxygenation Level Dependent (BOLD) signal<br /><br>changes in the auditory cortex in deaf adults and the difference in BOLD signal<br /><br>changes in the auditory cortex in response to visual stimuli between pre- and<br /><br>postlingually deaf adults.<br /><br><br /><br>The secondary parameter of the memory experiment is the difference in percent<br /><br>correct scores in spatial and temporal memory tasks between pre- and<br /><br>postlingual deaf adults.</p><br>