Detection of Immunotoxic Gluten Peptides in Feces
- Conditions
- Celiac Disease
- Interventions
- Other: Detection of gluten in feces
- Registration Number
- NCT01478867
- Lead Sponsor
- University of Seville
- Brief Summary
The purpose of this study is to monitor of gluten-free diet compliance in celiac patients by assessment of gliadin 33-mer equivalent epitopes in feces.
- Detailed Description
Certain immunotoxic peptides from gluten are resistant to gastrointestinal digestion and can interact with celiac patient factors to trigger immunological response. Gluten-free diet (GFD) is the only effective treatment for celiac disease (CD) and its compliance should be monitored to avoid accumulative damage. However, practical methods to monitor diet compliance and to detect the origin of an outbreak of celiac clinical symptoms are not available.
This study assesses the capacity to determine the gluten ingestion, and to monitor the GFD compliance in celiac patients by detection of gluten and gliadin 33-mer equivalent peptidic epitopes in human feces.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 53
- Celiac patient
- 1-12 years old
- Written informed consent
- Known inflammatory bowel diseases
- Participation in any other studies involving investigational concomitantly or within two weeks prior to entry into the study and during the course of the study
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Celiac patients Detection of gluten in feces -
- Primary Outcome Measures
Name Time Method Monitoring of gluten-free diet compliance in celiac patients April-July 2011 (3 months) Usual gluten diet for celiac (home diet not modified for this trial)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Seville
🇪🇸Seville, Spain