Differences in inflammatory and hemostatic response in cardiac surgery patients operated with conventional Cardiopulmonary Bypass (CPB) versus Minimized Extracorporeal Circulation (MECC).
Completed
- Conditions
- inflammation and hemostase and extracorporal circulation1001108210003184
- Registration Number
- NL-OMON30590
- Lead Sponsor
- Anesthesiologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 32
Inclusion Criteria
Patients> 18 years undergoing elective CABG with Cardiopulmonary bypass (CPB) in the Antonius hospital in Nieuwegein
Exclusion Criteria
Emergency patients, patients with inborn coagulation disorders and patients on immunosuppressive therapy.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary objective of this study is to define differences in the<br /><br>inflammatory response, coagulation, and fibrinolysis in CABG patients with MECC<br /><br>or conventional CPB.<br /><br>To compare inflammation and coagulation activation between MECC and<br /><br>conventional CPB patients several inflammatory and coagulation parameters in<br /><br>the blood are measured. Thromboelastography (TEG) is used to compare the<br /><br>hemostatic process between the groups.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Differences in blood product transfusion numbers, hospital and ICU length of<br /><br>stay, bloodloss and mechanical ventilation duration, and myocardial damage (CK><br /><br>180 U/l with CK-MB > 10% of total and troponine-T> 0,1).</p><br>