Acute and Chronic inflammatory responses induced by smoking in individuals being susceptible and non-susceptible for development of COPD: from specific disease phenotyping towards novel therapy (study 2).
- Conditions
- emphysema10046304chronic obstructive bronchitis (COPD)
- Registration Number
- NL-OMON32401
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 300
*Age *18 and *75 years
*Age, pack years, FEV1/FVC and FEV1% predicted must fit in one of the 9 groups of table 4.1 (see protocol )
*Physically and mentally able to undergo the total study protocol
*Written informed consent
*Participation in another study
* Alpha-1-antitrypsin deficiency
* Selected grade 1-3 co-morbidity listed in the ACE-27 (areas marked red)
* Active pulmonary infection like tuberculosis, pneumonia, flue, tracheobronchitis
* Active extra-pulmonary infection like hepatitis A-C, cystitis, gastro-enteritis etc
*Pulmonary diseases like sarcoidosis, pulmonary fibrosis, silicosis, hypersensitivity pneumonitis, asthma
*Life threatening diseases like carcinoma, AIDS (including HIV+), acute leukaemia etc
*Medication that may affect the results of the study: NSAID*s, immunosuppressive agents like prednisolon, metotrexate, azathioprine
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method