Clinical manifestations and inflammatory profiles in serum and skin of patients with neutrophilic dermatoses associated with adult onset immune deficiency due to autoantibodies to Interferon-gamma (IFN-γ)

Not Applicable

• Conditions: Clinical manifestations and inflammatory profiles in serum and skin of patients with neutrophilic dermatoses associated with adult onset immune deficiency due to autoantibodies to Interferon- gamma (; neutrophilic dermatoses; autoantibody interferon- gamma; skin findings; cytokines; chemokines; adhesion molecules; immunoglobulin (IgG) subclass

• Registration Number: TCTR20171103001
• Lead Sponsor: ational Research Management System : NRMS

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-11-03
• Study Completion: 2018-12-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. age 18-60 years old
2. evidence of Anti-IFN Ƴ autoantibodies by one of these techniques
luciferace immunoprecipitation system (LIPS), anti-IFN Ƴ autoantibody ELISA, particle-based technique, immunobloting technique, modified competitive inhibition assay using Bioplex cytokine assay
3. negative for anti-HIV antibody
4. equal or more than 2 times infects below agents and confirmed by culture, PCR or biopsy
-nontuberculous mycobacterium (NTM)
-disseminated fungal infections (e.g., penicilliosis marneffei, cryptococcosis, histoplasmosis)
-disseminated herpes zoster infection
non-typhoidal Salmonella bacteremia

Exclusion Criteria

1.history of cancer
2.using corticosteroids or other immunosuppressive agents within 4 weeks before screening or day that found opportunistic infection

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical manifestation, opportunistic infection and response to treatment 0 months, 3 months, 6 months, 12 months physical examination,Compare cytokines, chemokines and adhesion molecule between during neutrophilic dermatosis and non 0 months, 3 months, 6 months, 12 months ProcartaPlex® Multiplex Immunoassay Panels ,Relationship of cytokines in serum and skin of neutrophilic dermatoses 0 months, 3 months, 6 months, 12 months polymerase chain reaction (PCR) and immunohistochemistry

Secondary Outcome Measures

Name	Time	Method
Relationship of autoantibody levels and autoantibody subclasses to IFN-γ with skin manifestation 0 months, 3 months, 6 months, 12 months anti-IFNγ autoantibodies ELISA