Acute versus chronic inflammation: analysis of the T-cell function in the tonsilla palatina as surrogate marker of the immune status with patients with peritonsillar abscess versus patients with chronic tonsillitis
- Conditions
- J35.1J35.0J36Peritonsillar abscessChronic tonsillitisHypertrophy of tonsils
- Registration Number
- DRKS00007801
- Lead Sponsor
- Integriertes Forschungs- und Behandlungszentrum Sepsis und SepsisfolgenKlinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
All patient groups:
1. male or female patients, age at least 18 years
2. written informed consent
Only patient group A:
patients with peritonsillar abscess and emergent tonsillectomy
Only patient group B:
patients with chronic tonsillitis (with 3 or more episodes of recidival acute tonsillitides per year) and scheduled for routine tonsillectomy
Only patient group C:
patients without acute or chronic tonsillitis, but scheduled for routine tonsilectomy due to rhonchopathy or obstructive sleep apnea syndrome
Exclusion Criteria
1. therapy with steroids or other immunosuppressive therapy
2. severe chronic diseases in medical history
3. Therapy with coagulation inhibitors or abnormally low coagulation status
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference in the T cell response of patients with peritonsillar abscess, chronic tonsillitis and tonsil hyperplasia regarding activation, proliferation and apoptosis and thereby investigate the existence of T cell specific parameters to systemic and local inflammation
- Secondary Outcome Measures
Name Time Method Investigation of the use of the tonsils, as an easily available secondary lymphoid organ, for the determination of the immune status of patients with severe local inflammatory reaction to sepsis