Systemic versus local inflammation: Analysis of tonsillar T-cell function as a surrogate marker of the immune status in sepsis versus chronic tonsillitis
- Conditions
- A41.9J35.0J35.1Sepsis, unspecifiedChronic tonsillitisHypertrophy of tonsils
- Registration Number
- DRKS00005313
- Lead Sponsor
- Integriertes Forschungs- und Behandlungszentrum Sepsis und SepsisfolgenKlinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting stopped after recruiting started
- Sex
- All
- Target Recruitment
- 9
Group 1 (sepsis patients): adult patients who are asked two weeks after the diagnosis of severe sepsis and / or septic shock and written consent to provide a piece of their tonsils
Group 2 (chronic tonsillitis): adult patients with 3 or more episodes of recurrent acute tonsillitis per year that are scheduled for routine tonsillectomy
Group 3 (tonsil hyperplasia): adult patients without acute or chronic tonsillitis in history that are scheduled for routine tonsillectomy due to rhonchopathy or obstructive sleep apnea syndrome
Group 1 (sepsis patients): neuromuscular diseases, alcohol abuse, steroid therapy for asthma, COPD and patients likely to die within less than 24 hours, patients after tonsillectomy
Group 2 and 3 (chronic tonsillitis and tonsil hyperplasia): sepsis, immunodeficiency, severe chronic diseases in the medical history
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference in the T cell response of patients with sepsis, chronic tonsillitis and tonsil hyperplasia regarding activation, proliferation and apoptosis and thereby investigate the existence of T cell specific parameters to systemic and local inflammation
- Secondary Outcome Measures
Name Time Method Investigation of the use of the tonsils, as the only available secondary lymphoid organ, for the determination of the immune status of patients with sepsis