Disease occurrence And Inflammation in relation to Raw cow*s milk consumption in elderlY people.
Recruiting
- Conditions
- inflammatie-gerelateerde ziekteninfectieziektenInflammation-related disease1000381610019815
- Registration Number
- NL-OMON49627
- Lead Sponsor
- Wageningen Universiteit
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 5400
Inclusion Criteria
• At least 18 years of age
• Speaks Dutch
• Works or lives at a dairy farm
For the pilot study: at least 60 years of age
Exclusion Criteria
• A self-reported milk allergy or sensitivity to dairy ingredients
• Mental status that is incompatible with the proper conduct of the study
• Personnel of FrieslandCampina or Wageningen University & Research, department
of Cell Biology and Immunology or Human Nutrition and Health
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main endpoint of the cohort study is the prevalence and incidence over<br /><br>time (if budget allows) of inflammation-related disease. The main study<br /><br>parameter of the feasibility study is the difference in age-related<br /><br>inflammatory markers IL-6, CRP, and sVCAM in serum between the two milk groups<br /><br>(mainly raw versus mainly UHT-processed cow*s milk).</p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary outcome of the cohort study is the prevalence and incidence over<br /><br>time (if budget allows) of auto-immune and infectious disease. The secondary<br /><br>outcomes of the pilot study are differences and variances in serum levels of<br /><br>the additional inflammatory markers TNF-a, sICAM-1, IL1RA. </p><br>