Prone positioning and anterior chest wall loading to homogenize ventilation distribution in patients with acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenatio

Not Applicable

Recruiting

• Conditions: J80; Adult respiratory distress syndrome

• Registration Number: DRKS00033518
• Lead Sponsor: niversitätsmedizin Mannheim

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-01-29
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

Severe acute respiratory distress syndrome (ARDS) with PaO2/FiO2 < 100 mmHg
Treatment with veno-venous extracorporeal membrane oxygenation

Exclusion Criteria

Age < 18 years, contraindications to prone positioning, pregnancy, presence of a cardiac pacemaker and/or implanted defibrillator, and life expectancy < 24 hours.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Transpulmonary Driving Pressure during ultraprotective ventilation<br>The measurements are conducted and compared in the supine position, prone position, and during anterior chest wall loading.

Secondary Outcome Measures

Name	Time	Method
This study evaluates the effects of prone positioning and anterior chest wall loading on the mechanics of the partitioned respiratory system (lung and chest wall), pulmonary ventilation and perfusion distribution, hemodynamics, and gas exchange.