Effect of fluoxetine on the functional recovery of patients with cerebrovascular accident
- Conditions
- Cerebral ischemic stroke.Cerebral infarction due to thrombosis of cerebral arteries
- Registration Number
- IRCT201112228490N1
- Lead Sponsor
- Guilan University of Medical Science, Vice chancellor for research and technology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
informed consent; unilateral occlusion of middle cerebral artery trunk; resident in Rasht; Admission NIHSS< 20; No history of alcohol abuse; No history of insomnia, epilepsy; No previous history of cerebral hemorrhage and heart of cerebral stroke; No previous history of systemic diseases of other organs, including liver failure and kidney; Absence of cardiac pace maker, severe neuropathy, systemic vascular disease or major affective disorders; Absence of concomitant stroke in an area other than the stroke of the middle cerebral artery. Exclusion criteria: Dissatisfaction of patient during the study; Occurrence of serious adverse drug affects at any time during drug administration; Alcohol abuse during the study period; Occurrence of Post Stroke Depression (PSD) concomitant use of the mono amine oxidase inhibitors or serotonergic drugs such as tricyclic antidepressants and SSRI.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Disability. Timepoint: On admission day, on discharge day, 1 and 3 month later. Method of measurement: modified Rankin Scale (mRS).;Performance in basic Activities of Daily Living. Timepoint: On admission day, on discharge day, 1 and 3 month later. Method of measurement: Barthel Index.;Functional recovery. Timepoint: On admission day, on discharge day, 1 and 3 month later. Method of measurement: National Institutes of Health Stroke Scale (NIHSS).;Depression. Timepoint: On admission day, on discharge day, 1 and 3 month later. Method of measurement: Beck Depression Inventory (BDI) questionnaire.
- Secondary Outcome Measures
Name Time Method Cerebral blood flow changes of middle cerebral artery. Timepoint: On admission day, on discharge day. Method of measurement: Transcranial Doppler (TCD).