Genetic Basis of Neuroblastoma Tumorigenesis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9,350
- 试验地点
- 2
- 主要终点
- Neuroblastoma predisposition genes
研究概览
简要总结
This laboratory study is looking at genes in participants with neuroblastoma or noncancerous conditions. Identifying genes related to cancer may help in the study of cancer. It may also help doctors predict who is at risk of developing neuroblastoma.
详细描述
OBJECTIVES:
I. Perform a whole genome scan for association of neuroblastoma with single nucleotide polymorphisms (SNP) and SNP haplotypes.
II. Identify true disease-associated SNP alleles using a customized genotyping platform enriched for haplotype analyses in an independent sample set.
III. Validate disease-associated SNP alleles and haplotypes in a final independent sample set.
IV. Identify neuroblastoma predisposition genes.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosis of neuroblastoma
- •Banked constitutional and genomic DNA within COG-ANBL00B1 Neuroblastoma Biology protocol or another COG Biology Protocol
- •At least 1.0 ?g of DNA available
- •Control (age, race, and gender-matched):
- •No diagnosis of cancer
- •May have other conditions, including any of the following:
- •Inflammatory bowel disease
- •Attention-deficit disorder
排除标准
- 未提供
结局指标
主要结局
Neuroblastoma predisposition genes
时间窗: Up to 4 years
Single nucleotide polymorphism (SNP) allele disease association
时间窗: Up to 4 years
SNP haplotype disease association
时间窗: Up to 4 years
Validation of SNP allele and haplotype disease association
时间窗: Up to 4 years
SNP association with phenotypic subsets (i.e., high-risk vs no high-risk disease; MYCN amplification vs no MYCN amplification)
时间窗: Up to 4 years
次要结局
未报告次要终点