A Randomized, Controlled, Cross-over Study of the Effect of Certain Breakfasts on Appetite Control.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Appetite
- Sponsor
- St. Boniface Hospital
- Locations
- 2
- Primary Endpoint
- Satiety
- Status
- Withdrawn
- Last Updated
- 9 years ago
Overview
Brief Summary
This clinical trial is being conducted to study whether eating certain meals will reduce your desire to eat and for a longer period of time compared to others and to determine the post-meal glucose response associated with each of these breakfast foods.
Detailed Description
The study is divided into 3 phases. Each phase involves eating one of 3 different breakfasts every day for 1 month. The order of the breakfast products is random. During each phase participants will come to the research clinic for 4 visits (1 per week) for assessment of appetite-related sensations. Gastric emptying will be assessed at 1 visit per phase and post prandial glucose response will be measured at 1 visit per phase (Asper site only).
Investigators
Dr. Heather Blewett
Principal Investigator
St. Boniface Hospital
Eligibility Criteria
Inclusion Criteria
- •Healthy Males and females (not pregnant or lactating) aged 19 to 60 years.
- •Body mass index: 18.5-30 kg/m2.
Exclusion Criteria
- •A change in medication (dose or type) or medical event requiring hospitalization within the past month.
- •Daily tobacco use.
- •Physical Activity Level \>1.
- •Eat meals at irregular or unusual times.
- •Food allergy, aversion or unwillingness to eat study foods.
- •Use of any prescription or non-prescription drug, herbal or nutritional supplement known to affect appetite or blood sugar.
- •Presence of a gastrointestinal disorder.
- •Taking drugs that affect gastric emptying.
- •Score \>65% on any 1 of the 3 categories of the Three Factor Eating Questionnaire-R18.
Outcomes
Primary Outcomes
Satiety
Time Frame: before the breakfast and every 30 minutes after breakfast for 4 hours
Total area under the curve (AUC) for hunger, fullness, desire to eat, and prospective consumption scales
Gastric emptying rate
Time Frame: before the breakfast and every 15 minutes after breakfast for 4 hours
13C-Octanoic Acid will be incorporated into the breakfast food. Rate of gastric emptying will be determined by measuring 13C in breath samples.
Secondary Outcomes
- Glucose and Insulin(before the breakfast and at 15, 30, 45, 60, 90 and 120 minutes after the the breakfast.)
- Kilocalories(1 day)