Postoperative Analgesic Effect of Nefopam
- Registration Number
- NCT02561494
- Lead Sponsor
- Seoul National University Bundang Hospital
- Brief Summary
Nefopam will be administered to the patients undergoing laparoscopic gastrectomy under the total intravenous anesthesia (TIVA).
The investigators will evaluate whether the nefopam can decrease the total amount of remifentanil administered during the operation, which will reduce the acute opioid tolerance and following consumption of fentanyl during postoperative period.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 78
Inclusion Criteria
- Early or advanced gastric cancer
Exclusion Criteria
- Refusal
- Use of preoperative analgesic drugs
- Pregnancy
- Recurred gastric cancer
- Seizure
- Cardiac disease
- Monoamine oxidase inhibitor
- Urologic disease
- Previous intrabdominal surgery
- Body mass index > 30 or < 16
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Control Saline Intravenous normal saline 2 ml is given slowly as a placebo before the anesthesia induction and after finishing anesthesia. Nefopam Nefopam Intravenous nefopam 20 mg is given slowly before the anesthesia induction and after finishing anesthesia.
- Primary Outcome Measures
Name Time Method Change of the administered fentanyl dose from postoperative 6 h to postoperative 5 day postoperative 6 h, postoperative 1 day, postoperative 2 day, postoperative 3 day, postoperative 5 day
- Secondary Outcome Measures
Name Time Method Change of the pain score from postoperative 6 h to postoperative 5 day postoperative 6 h, postoperative 1 day, postoperative 2 day, postoperative 3 day, postoperative 5 day
Trial Locations
- Locations (1)
Seoul National University Bundang Hospital
🇰🇷Seongnam, Gyeonggi, Korea, Republic of