Comparison of postoperative analgesic effects of two different doses of intravenous dexmedetomidine and lidocaine in patients undergoing laparoscopic hysterectomy
Not Applicable
Recruiting
- Conditions
- Not Applicable
- Registration Number
- KCT0008263
- Lead Sponsor
- Samsung Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 120
Inclusion Criteria
(1) Aged between 18 and 70 (19-69 years old )
(2) American society of anesthesiologist physical status I, II
Exclusion Criteria
(1) history of adverse events or allergic to lidocaine and dexmedetomidine
(2) obese: Body Mass Index = 35 kg/m2
(3) cardiovascular disease: severe cardiac dysfunction, bradycardia, atrioventricular block, coronary artery disease
(4) electrolyte imbalance
(5) significant hepatic/renal impairment
(6) neurological disorder: seizure, central nervous system disease
(7) History of medication: opioid, a2 agonist, alcohol abuse, antidepressant
(8) psychiatric disorder or inability to comprehend the study protocols
(9) pregnant or lactating women
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method opioid consumption during 24h after surgery (morphine equivalent dose)
- Secondary Outcome Measures
Name Time Method postoperative opioid consumption (morphine equivalent dose);Resting pain severity (Numeric rating scale: 11point scale, 0= no pain, 10= worst imaginable pain) ;opioid related side efffect (nausea and vomiting, dizziness, somnolence, and respiratory depression);Time to first flatus;Time to weaning for normal diet ;antiemetics admnistration ;composite of any complication;recovery from anesthesia and surgery (QoR15K);recovery profile at emergence (time to emergence, time to extubation, coughing grade);emergence delirium (RASS)